Recent synthetic methods towards the –OCHF2 moiety

The fluorine atom and fluorinated substituents are currently key motifs in pharmaceutical agrochemical active ingredients, since they often beneficially modulate the physico-chemical biological properties of latter when installed place a hydrogen substituent. Among such moieties, –OCHF2 is emerging as an interesting group, which notably capable forming bond. These appealing have led to growing need for introduction methods this group. In review we summarize all current allowing access moiety. We will hence discuss procedures applicable either aromatic or aliphatic substrates, based on different disconnections, including difluoromethylation alcohols, radical addition onto arenes.